Anti-VEGF agents are medications that are in use in the treatment of various common eye diseases such as: Wet Age-related Macular Degeneration (ARMD), Diabetic Macular Edema, and Retinal Vein Occlusion. There are several anti-VEGF agents now commonly used, including Ranibizumab (Lucentis), Aflibercept (Eylea), and Bevacizumab (Avastin). These agents are delivered into the eye by an injection. The procedure is performed in the office and is well tolerated with topical anesthetic drops.